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排序方式: 共有223条查询结果,搜索用时 50 毫秒
1.
Intelligent Service Robotics - In this paper we propose a robotic system for picking peppers in a structured robotic greenhouse environment. A commercially available robotic manipulator is equipped... 相似文献
2.
Claudia Giuseppina Fresta Giuseppe Caruso Annamaria Fidilio Chiara Bianca Maria Platania Nicol Musso Filippo Caraci Filippo Drago Claudio Bucolo 《International journal of molecular sciences》2020,21(23)
Activation of P2X7 signaling, due to high glucose levels, leads to blood retinal barrier (BRB) breakdown, which is a hallmark of diabetic retinopathy (DR). Furthermore, several studies report that high glucose (HG) conditions and the related activation of the P2X7 receptor (P2X7R) lead to the over-expression of pro-inflammatory markers. In order to identify novel P2X7R antagonists, we carried out virtual screening on a focused compound dataset, including indole derivatives and natural compounds such as caffeic acid phenethyl ester derivatives, flavonoids, and diterpenoids. Molecular Mechanics/Generalized Born Surface Area (MM/GBSA) rescoring and structural fingerprint clustering of docking poses from virtual screening highlighted that the diterpenoid dihydrotanshinone (DHTS) clustered with the well-known P2X7R antagonist JNJ47965567. A human-based in vitro BRB model made of retinal pericytes, astrocytes, and endothelial cells was used to assess the potential protective effect of DHTS against HG and 2′(3′)-O-(4-Benzoylbenzoyl)adenosine-5′-triphosphate (BzATP), a P2X7R agonist, insult. We found that HG/BzATP exposure generated BRB breakdown by enhancing barrier permeability (trans-endothelial electrical resistance (TEER)) and reducing the levels of ZO-1 and VE-cadherin junction proteins as well as of the Cx-43 mRNA expression levels. Furthermore, HG levels and P2X7R agonist treatment led to increased expression of pro-inflammatory mediators (TLR-4, IL-1β, IL-6, TNF-α, and IL-8) and other molecular markers (P2X7R, VEGF-A, and ICAM-1), along with enhanced production of reactive oxygen species. Treatment with DHTS preserved the BRB integrity from HG/BzATP damage. The protective effects of DHTS were also compared to the validated P2X7R antagonist, JNJ47965567. In conclusion, we provided new findings pointing out the therapeutic potential of DHTS, which is an inhibitor of P2X7R, in terms of preventing and/or counteracting the BRB dysfunctions elicited by HG conditions. 相似文献
3.
Two subroutines have been developed which permit users of the TRNSYS programme to calculate the parameters of ambiental comfort (PMV and PPD).The first subroutine deals with the calculation of the view factors inside a room for all the values of the spatial coordinates and, thus, permits the average radiant temperature to be calculated in every position. The second subroutine has been developed in accordance with the indications of the ISO 7730 standard.Both subroutines have been validated and then interfaced to TRNSYS.The integrated programme has been utilised to compare the performances of different heating systems in terms of energy consumption and comfort, maintaining the temperature of the interior constant for different climatic conditions. 相似文献
4.
Andrea Ciancone Mauro Luigi Drago Antonio Filieri Vincenzo Grassi Heiko Koziolek Raffaela Mirandola 《Software and Systems Modeling》2014,13(4):1269-1290
Automatic prediction tools play a key role in enabling the application of non-functional requirements analysis, to simplify the selection and the assembly of components for component-based software systems, and in reducing the need for strong mathematical skills for software designers. By exploiting the paradigm of Model-Driven Engineering (MDE), it is possible to automatically transform design models into analytical models, thus enabling formal property verification. MDE is the core paradigm of the KlaperSuite framework presented in this paper, which exploits the KLAPER pivot language to fill the gap between design and analysis of component-based systems for reliability properties. KlaperSuite is a family of tools empowering designers with the ability to capture and analyze quality of service views of their systems, by building a one-click bridge towards a number of established verification instruments. In this article, we concentrate on the reliability-prediction capabilities of KlaperSuite and we evaluate them with respect to several case studies from literature and industry. 相似文献
5.
Idilio Drago Rafael R. R. Barbosa Ramin Sadre Aiko Pras Jürgen Schönwälder 《Journal of Network and Systems Management》2011,19(2):298-304
Following the success of the First Workshop on the Usage of NetFlow/IPFIX (Pras et al. in J Netw Syst Manag 17(4), 2009) in 2008, the European EMANICS Network of Excellence organized a second workshop
in October 2009, held at Jacobs University Bremen. This report summarizes the workshop and presents its main conclusions. 相似文献
6.
Radu-Emil Precup Marius L. Tomescu Mircea-Bogdan Rădac Emil M. Petriu Stefan Preitl Claudia-Adina Dragoş 《Expert systems with applications》2012,39(9):8288-8299
This paper suggests the performance improvement of fuzzy control systems (FCSs) for three tank systems using iterative feedback tuning (IFT). The stable design of Takagi–Sugeno–Kang fuzzy controllers is guaranteed by means of a stability theorem based on LaSalle’s global invariant set theorem formulated for a class of multi input-multi output (MIMO) nonlinear processes. An IFT algorithm characterized by setting the step size to guarantee the FCS stability is proposed. The theoretical approaches are applied in a case study that deals with the IFT-based stable design of fuzzy controllers dedicated to the level control of a cylindrical three tank system as a representative MIMO system. A set of experimental results for a laboratory setup illustrates the performance improvement. 相似文献
7.
Tomislav Haus Matko Orsag Stjepan Bogdan 《Journal of Intelligent and Robotic Systems》2014,74(1-2):45-57
The goal of the Spincopter project was to design an energy efficient aircraft capable of autorotation glide that could be used for both indoor and outdoor surveillance. This paper demonstrates how to utilize the self-rotating capability of the Spincopter in order to acquire a 3D image of its environment and localize predefined object(s). The omnidirectional capabilities of such an UAV extends the otherwise very limited field of view of conventional cameras usually used for aerial photography and surveillance. The paper presents the theoretical background and the actual implementation of such a system. It presents the resulting images and offers a brief survey of the image quality. 相似文献
8.
Raúl E. Cian Micaela Albarracín Antonela G. Garzón Silvina R. Drago 《International Journal of Food Science & Technology》2022,57(8):4832-4839
Sorghum flour was heat treated for producing an instant dispersion ingredient. The precooked sorghum flour was added with ACE-I and DPP-IV inhibitory sorghum peptides (3.0 g peptide 100 g−1). The product was reconstituted in water, and peptide bioaccessibility was evaluated by equilibrium dialysis method after simulated gastrointestinal digestion. Total peptide dialysability of precooked sorghum flour added with sorghum peptides was higher than those obtained for precooked sorghum flour (315.9 ± 14.8 vs. 45.2 ± 5.6 µmol, respectively) (P < 0.05). The ACE-I and DPP-IV-IC50 values of the bioaccessible peptides from the bioactive product were lower than those obtained for precooked sorghum flour ingredient (1.04 ± 0.12 vs. 1.82 ± 0.09 and 0.86 ± 0.02 vs. 2.12 ± 0.08 mg protein mL−1, for ACE-I and DPP-IV, respectively) indicating a higher activity. Precooked sorghum flour was a good vehicle since it did not affect the bioaccessibility of ACE-I and DPP-IV inhibitory peptides provided by sorghum protein hydrolysate. 相似文献
9.
10.
Raúl E. Cian Silvina R. Drago Rolando J. González 《International Journal of Food Science & Technology》2012,47(7):1348-1353
The effect of pH on colour and iron content (Fe) of peptide fractions obtained from bovine haemoglobin concentrate (BHC) hydrolysates was studied. Four hydrolysates were obtained using three enzymes: Protex‐6‐L (P), Fungal–Protease–Concetrate (FC) and Flavourzyme (F). BHC and its hydrolysates (P, FC, P + F, FC + F) were fractioned at pH 4.5, 7.0 and 9.5. Solubility and Fe from different fractions were measured. Correlations between CIELAB colour parameters and Fe from different fractions were analysed. The colour from different fractions varied from red to yellow (a* and b* positives). Lightness values (L*) ranged from twenty‐four to seventy. FC4.5 and FC + F4.5 fractions were the clearest and yellow (higher L*, b*, h), while BHC9.5 and P + F9.5 fractions had the lowest values of L*, b* and h. There was an inverse linear relationship between b* and L* parameters and Fe from fractions. This relationship could be associated with the pH of extraction. As pH increases Fe significantly increases and lower b* and L* values were obtained. 相似文献